These firms rose to the top of the ranks on the basis of the quality of their science and the soundness of their business plans. Each company is described in depth in the accompanying profile.
Advanced material technology in which porous organic cage molecules capture sub-nanometre-size pollutants such as formaldehyde 500 times more effectively than activated carbon.
Software for analysis of cardio computed tomography (CT) scans to identify vascular inflammation and the risk of heart attack.
Drug to treat post-traumatic stress disorder by blocking the consolidation of traumatic memories in the brain.
Drug to help people control their weight by suppressing their appetite.
An oral drug for treating insulin-dependent diabetes by turning certain gut cells into β-like cells that produce insulin in response to blood glucose levels.
A medical device to integrate microwave technologies with conventional colonoscopy. The technology identifies polyps 360º inside the colon without changing the clinical practice and diagnoses the grade of dysplasia of such identified polyps.
Enhanced magnetic resonance imaging (MRI) system for early diagnosis of dementia.
Machine learning algorithm to develop a new class of diagnostic biomarker that uses molecular signatures to characterize a single cell's identity. Such biomarkers could help researchers to understand the function of rare, uncharacterized and previously unknown cell types and thus point towards potential new disease therapies.
Networked wireless sensor system to monitor neonatal vital signs (including electrocardiogram data, blood flow volume and skin temperature) in real-time with clinical-grade precision.
Winner of the Spinoff Prize 2020
Ultrasound wearable device to measure accurately, continuously and non-invasively the blood pressure waveform. The device allows blood pressure to be recorded within deep arteries continuously without the need for clinical staff supervision.
The judges selected not only 12 finalists but also 32 other university spin-offs — the Ones to Watch. All 44 companies are listed below. Click on the filter button to sort the companies by their areas of focus.
44 companies shown in list.
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Imaging agents for positron emission tomography (PET) scans to help diagnose cancer.
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Drug for type 2 diabetes and obesity that works by modulating nutrient contact with the bowel mucosa and thereby lowering the glucose response.
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Wound care patch and spray that can kill bacteria and prevent infections in skin wounds.
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Cell therapies for type 1 diabetes and other autoimmune diseases, with potential applications in transplantation and certain forms of cancer.
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Bioenzymatic fuel cell power sources using enzymes and carbon paper provide power for wearable and disposable electronics such as continuous glucose monitors for diabetes and digital pregnancy tests.
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Advanced material technology in which porous organic cage molecules capture sub-nanometre-size pollutants such as formaldehyde 500 times more effectively than activated carbon.
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Asseses genetic and epigenetic DNA markers to monitor a patient's risk for heart disease.
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Software for analysis of cardio computed tomography (CT) scans to identify vascular inflammation and the risk of heart attack.
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Developing fluorophores to be used in single and multiphoton bioprobes in flow cytometry and live tissue imaging.
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Technology to improve manufacturing yields and boost the efficiency of compound semiconductor devices such those used in lasers, light-emitting diodes (LEDs) and photodetectors.
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Technology that allows small-molecule anti-cancer agents to penetrate cell membranes only at the low pH characteristic of the tumour microenvironment, thus selectively releasing drug molecules directly within tumour cells while limiting toxicity to healthy tissue.
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Technology for continuous, non-invasive blood pressure monitoring.
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Liquid biopsies to detect cancer based on metabolite biomarkers.
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Drug to treat post-traumatic stress disorder by blocking the consolidation of traumatic memories in the brain.
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Qubits (or quantum bits) for what could be the world's first desktop quantum computer.
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Drug to help people control their weight by suppressing their appetite.
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An oral drug for treating insulin-dependent diabetes by turning certain gut cells into β-like cells that produce insulin in response to blood glucose levels.
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Wearable device to sense wrist rigidity to aid the placement of electrodes during deep brain stimulation surgery to treat Parkinson's disease.
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General-purpose photonic processors capable of programming high-speed light signals on-chip for applications such as 5G communication, autonomous driving, quantum computing and the Internet of things.
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Chromatography-free purification solutions to improve productivity, lower cost and simplify scale-up in the production of therapeutics such as monoclonal antibodies and gene therapies.
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Artificial-intelligence (AI) system to guide chemistry research, from proposing new molecules with specific properties to designing a robot-assisted laboratory workflow to synthesize these molecules.
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Biolubricants for use in applications such as artificial knees and hips.
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Combining stem cell research with tissue engineering technologies to develop personalized treatments for a variety of indications including myocardial infarction, spinal cord injury, age-related macular degeneration and Parkinson's disease.
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In people with cancer, networks of altered protein–protein relationships generate a flow of information, which direct the tumour cells' development and progression. MEDPNC deciphers the structure of these networks in each individual patient and predicts the optimal personalized drug combinations for treatment.
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A medical device to integrate microwave technologies with conventional colonoscopy. The technology identifies polyps 360º inside the colon without changing the clinical practice and diagnoses the grade of dysplasia of such identified polyps.
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Developing a system to manage mushroom growth for food and turning the waste from the fungus into biomaterials to replace plastic and construction materials.
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Precision delivery of cancer immunotherapies.
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Battery heated clothing made possible by integrating silver nanowires into fabrics.
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Makes an acoustic belt that listens, records and analyses gut noises, using algorithms to non-invasively diagnose and monitor irritable bowel syndrome and other gut disorders.
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Enhanced magnetic resonance imaging (MRI) system for early diagnosis of dementia.
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Develops blueprints for quantum computers to solve optimization problems as well as the appertaining software called ParityOS, which can be used to solve optimization problems
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Monoclonal antibodies to treat disease in dogs and cats.
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Prognostic tests for immune-mediated and autoimmune diseases.
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Tool that uses artificial-intelligence (AI) algorithms to analyse bone-marrow biopsy data as a way to help physicians choose a personalized treatment approach for people with the blood cancer multiple myeloma.
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Developing genetically engineered drugs to treat amyotrophic lateral sclerosis and other protein-misfolding diseases.
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Organ-on-a-chip platforms to help cosmetic and pharmaceutical research laboratories screen the safety and efficacy of chemicals and formulations reliably and efficiently, replacing animal testing.
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Packages therapeutic nucleic acids in virus-like nanoparticles, enabling delivery of specific types of nucleic acids to specific types of cells.
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Machine learning algorithm to develop a new class of diagnostic biomarker that uses molecular signatures to characterize a single cell's identity. Such biomarkers could help researchers to understand the function of rare, uncharacterized and previously unknown cell types and thus point towards potential new disease therapies.
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Networked wireless sensor system to monitor neonatal vital signs (including electrocardiogram data, blood flow volume and skin temperature) in real-time with clinical-grade precision.
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Ultrasound wearable device to measure accurately, continuously and non-invasively the blood pressure waveform. The device allows blood pressure to be recorded within deep arteries continuously without the need for clinical staff supervision.
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Treatment for vitiligo.
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Therapies targeted to remove the threat of antimicrobial resistance. The company’s lead product, TBX101, aims to treat patients carrying gut antimicrobial-resistant bacteria, resulting in an antibiotic sensitive gut microbiome.
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Developing a system that uses arrays of microfluidic separation devices for application in harvesting biological cells from large scale culture or fermentation operations such as those used in the production of food, nutraceuticals, beverages, biofuels, insulin, monoclonal antibodies and therapeutic proteins.
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Technology to improve the efficiency of CRISPR gene editing for high-throughput screening.
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